Yet another post in the series of recommendations. You can see the others by clicking on the category.
Dot Net Rocks – brilliant long-running show on software development, focusing on the Microsoft stack. Archives right back to show one. Great for researching in to topics in .Net development. Excellent audio-quality with fun and humorous content.
The Tim Ferriss Show – great guests, with insightful and diverse content on just about every topic that matters in life.
Software Engineering Daily – another good software related show, with always interesting and sometimes relevant content. Seemingly heavily driven by content relevant to a US software context.
Ruby Rogues – one of the devchat series of software podcasts, Ruby is a modern and highly regarded framework, especially for web-based development. The shows archive contains many general software engineering topics that are applicable to all software regardless of the language used.